单娟,博士,副教授,从事免疫学教学和科研工作,承担国家自然科学基金青年课题1项、发表SCI论文10余篇。
一、 科研项目
1.瘦素致Th17/Treg失衡对类风湿关节炎的作用及机制研究,国家自然科学基金青年项目,编号:81401359 2015.01-2018.12,负责人,结题,国家级
2.mTOR抑制剂在类风湿性关节炎中的免疫调节作用和机制研究,校基金自然科学类项目,编号:CTZ13-014,2014.01-2015.12,负责人,结题,校级
二、 科研论文 (近5年)
1.Shan J*, Jin H, Xu Y. T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus. Front Immunol . 2020 May 22;11:1027.
2.Shan J*, Zhang J. Impact of obesity on the efficacy of different biologic agents in inflammatory diseases: a systematic review and meta-analysis. Joint Bone Spine. 2019;86(2):173-183
3.Chen X, Li S, Long D, Shan J*, Li Y*. Rapamycin facilitates differentiation of regulatory T cells via enhancement of oxidative phosphorylation. Cell Immunol. . 2021 Jul; 365:104378.
4.Chen X, Feng L, Li S, Long D, Shan J*, Li Y*. TGF-β1 maintains Foxp3 expression and inhibits glycolysis in natural regulatory T cells via PP2A-mediated suppression of mTOR signaling. Immunol Lett . 2020 Oct; 226:31-37.
5. Zhang J#, Shan J#,*, Chen X, Li S, Long D, Li Y*. Celastrol mediates Th17 and Treg cell generation via metabolic signaling. Biochem Biophys Res Commun . 2018; 497(3):883-889